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  • thermal place preference
  • thermal hyperalgesia
  • thermal pain
  • temperature preference
  • thermal analgesia

Thermal Place Preference

The Thermal Place Preference Test (TPPT) is an advanced behavioral assay designed to evaluate thermal sensitivity and temperature-driven behavior in rodents. As described in Moqrich et al. (Science, 2005), TPPT is a significant evolution of the traditional hot plate and hot-cold plate tests. It enables researchers to finely quantify thermal hyperalgesia and cold allodynia in models of neuropathic pain, such as chronic constriction injury (CCI).

TPPT allows rats or mice to freely choose between two emperature-controlled plates, offering insights into their pain threshold, nociceptive responses, and inflammation-driven behavior.

Application: Chronic constriction injury, Cold allodynia, Neuropathic pain, Analgesic drug screening.

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Overview Specification FAQ How to Order
Overview

As advised by A. MOQRICH, and published in Moqrich et al (Science 2005, 307: 1468-72), the thermal place preference test (TPPT) was designed to finely assess thermal sensitivity in rodents. It can detect, quantify, and differentiate behavioral responses to cold stimuli between sham and chronic constriction injury (CCI) rodents.

The Thermal Place Preference Test, also call as 2 Temperatures Choice Nociception Test, based on two Hot Cold Plate (Temperature range from -5°C to 65 °C)，allows researchers to work on free moving animals (Rats and Mice) to choose their preferred place between 2 compartments set a different temperature. Our Thermal Place Preference adopts dynamic infrared scanning tracking technology to record the location of the rodents and automatically analyze the staying time and times in each compartment. TPPT enables a fine-grained assessment of thermal sensitivity that is relevant to the pathophysiological exploration of animal pain models and to the pharmacological assessment of analgesic drugs.

Features and Benefits

Features Benefits
Capacitive 8-inch LCD display, resolution: 800×600 Big display for easy operation
Wide range of temperatures (-5° to -65°) Able to conduct any sort of thermal sensitivity experiment, including severe cold allodynia.
Adopts precise PID control algorithm, will continuously collect temperature feedback to control heating/cooling. Control the current temperature more accurately.
Adopts high-performance 32-bit microcomputer control chip for temperature control. Ensure the accurate temperature.
Adopts dynamic infrared scanning tracking technology. Location of the rodents, staying time and times in each compartment automatically recorded.
Experimental temperature of placement on the plate and the first sign of nocifensive response such as paw licking or jumping can be recorded in real time.  
Data extraction from the Thermal Place Preference is straightforward by using a USB drive, in CSV format. Possibility to open files in Excel.

 

Advantages

  • Non-invasive and stress-free method for assessing pain perception
  • Suitable for both mice and rats – adjust settings with ease
  • Enhanced data accuracy with fully automated time/location tracking
  • Real-time behavioral monitoring of thermal aversion or preference
  • Flexible experimental design – explore a variety of temperature gaps and durations
  • Clean digital output ready for statistical analysis
Specification

Basic specification

Application Rat or Mouse
Commands 8-inch LCD display, resolution 800*600
Power 100-240 VAC, 50-60Hz, 300W
Sound Level < 60 dB (A)

Operation

Plate Temp. Range -5.0°C to +65°C (in 0.1°C steps)
Speed Fixed, progressive
Start/Stop By foot pedal switch
Detection High-performance 32-bit microcomputer control chip
Time display 0.01~600.00s
Time Display standard deviation <0.02 ‰ Seconds
Experimental data Time, temperature, mean, maximum value, minimum value
Place Preference data Dwell time/ Cross Times/Times of Left/Right compartment
Position display Current staying location/Time display
Data export By USB flash drive
Data storage 100 data

Thermal Place Preference Size

Container size 530×230×260mm (L x W x H)
Middle door thickness 15mm
Weight 23kg
FAQ

Q1: What is the difference between TPPT and the standard Hot Plate Test?
A: TPPT allows free movement and choice behavior, offering a more naturalistic and sensitive assessment of pain threshold, while the Hot Plate Test typically involves passive exposure.

Q2: Can I test both cold and heat sensitivity with TPPT?
A: Yes! Each plate can be set to a different temperature, allowing simultaneous evaluation of cold allodynia  and heat hyperalgesia.

Q3: Is the device suitable for both rats and mice?
A: Absolutely. The system supports both species, and experiment parameters can be adjusted accordingly.

Q4: How is data exported from the device?
A: Data is saved on a USB stick in CSV format, which can be opened directly in Excel or other analysis tools.

Q5: Does the system require a PC to operate?
A: No. The 8-inch touchscreen allows for standalone operation. However, for advanced analysis, you can export data to a PC.

How to Order
Item No. Product Description
SA707 Thermal Place Preference for Mice and Rats

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