Prepulse inhibition (PPI) is the phenomenon in which a weak prepulse stimulus attenuates the response to a subsequent startling stimulus. The stimuli are usually acoustic, light and tactile stimuli. Patients with schizophrenia and some other neuropsychiatric disorders have impaired PPI.Science’s Rodent Startle Reflex System allows for Pre-pulse inhibition and fear-potentiated startle protocols efficiently and economically. Animal models are widely used to test hopotheses linking genetic components of various diseases.
