Rodent Treadmill

Q. Is the treadmill limited to applicable for 5 mice and 5 rats?
A. By default, the treadmill is 5 lanes for mice or rats. And we offer customization lanes according to researchers’ demand.

Q. If we would like to do for both Rats and Mice, do we need to purchase 2 individual treadmill?
A. The treadmill can be used for both mice and rats, you don’t need to purchase 2 individual unit, you would only need to have two sets of covers and shock grids, one for mice and the other for rats. This design help you save a lot of cost.

Q. Is the treadmill controlled by a touch screen that comes with the device? Or via a software on a PC?
A. The treadmill is controlled via a touch screen that comes with the device, and it can be also controlled via the software on a PC.

Q. Can we program a specific session of treadmill in advance? 
A. Yes, 8 protocol setting is included in our software and the sectional acceleration can be set. the last program is saved as the default screen display.

Q: Do we need to set these 2 exhaustion modes together or either one will do? If these 2 modes ON together, for example, Warn is 3 and Shock is 30 sec, when the shock time reached to 30 sec, will the experiment will stop on this time before the warn reach to 3 times?
A: You do not need to set the 2-exhaustion mode in the same time. Usually, researchers not do this. And if you turn on these 2 modes in the same time, for example, warn: 3 and Shock is 30 sec, when the shock time reached to 30 sec while the Warn not reach to 3 times, the experiment will stop on this time before the warn reach to 3 times.)

Q: When the electric simulation stops, would there any electric on at this time for all the channels? And, when the electric shock will back after stop?
A: For the electric stimulation stop, it depends on 2 conditions:
1. Exhaustion mode: When the channel reaches to exhaustion mode, it stops electric stimulation.
2. General mode: When the channel reaches to the set experiment duration, it stops electric stimulation. And the electric shock will not recover until you start another new trial.

1. Daytime-restricted feeding enhances running endurance without prior exercise in mice

https://www.nature.com/articles/s42255-023-00826-7 

2. Cross-species metabolomic analysis identifies uridine as a potent regeneration promoting factor 

https://www.nature.com/articles/s41421-021-00361-3

3. Stabilization of heterochromatin by CLOCK promotes stem cell rejuvenation and cartilage regeneration 

https://www.nature.com/articles/s41422-020-0385-7 

4. Aerobic exercise promotes the expression of ATGL and attenuates inflammation to improve hepatic steatosis via lncRNA SRA

https://www.nature.com/articles/s41598-022-09174-0 

5. Moderate intensity exercise may protect cardiac function by influencing spleen microbiome composition

https://www.sciencedirect.com/science/article/pii/S2589004223027128 

6. MicroRNA-224-5p nanoparticles balance  homeostasis via inhibiting cartilage degeneration  and synovial  inflammation for synergistic alleviation of osteoarthritis

https://www.sciencedirect.com/science/article/abs/pii/S1742706123003367

7. Elimination of senescent cells byβ-galactosidase-targetedprodrug attenuates inflammation and restores physicalfunction in aged mice

8. MOTS-c and Exercise Restore Cardiac Function by Activating of NRG1-ErbB Signaling in Diabetic Rats

9. LRRK2 Deficiency Aggravates Sleep Deprivation-InducedCognitive Loss by Perturbing Synaptic Pruning in Mice

10. HMGB1- Promoted Neutrophil Extracellular Traps Contribute to Cardiac Diastolic Dysfunction in Mice

11. Piezo1-mediated M2 macrophage mechanotransduction enhances bone formation through secretion and activation of transforming growth factor-β1

12. Cadmium exposure impairs skeletal muscle function by altering lipid signature and inducing inflammation in C57BL/6J mice